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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 18244Generated: October 25, 2026

3-[N-(Benzyloxycarbonyl)-N-methylaminomethyl)-1-benzyl-1H-indole → 1-ethyl-3-(methylaminomethyl)-1H-indole

https://huagongshe.com/reaction/18244

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-[N-(Benzyloxycarbonyl)-N-methylaminomethyl)-1-benzyl-1H-indoleHCID 22139015—
Reactant3-[N-(Benzyloxycarbonyl)-N-methylaminomethyl]-1-isopropyl-1H-indoleHCID 22139078—
Product1-ethyl-3-(methylaminomethyl)-1H-indoleHCID 2213910187.3%

Reaction Steps

According to the procedure of Preparation 17 (c), except substituting 3-[N-(Benzyloxycarbonyl)-N-methylaminomethyl]-1-isopropyl-1H-indole (0.99 g, 2.98 mmole) for the 3-[N-(Benzyloxycarbonyl)-N-methylaminomethyl]-1-benzyl-1H-indole, the title compound (0.49 g, 82%) was prepared as a white solid: MS (ES) m/e 405 (2M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07741339B2
Source datasetuspto-grants-2010_06
ORD IDord-eb8cc8c9b4ed4843868b42bbcc93a8fb
Source noteuspto-grants-2010_06