HuagongsheHuagongshe Chemistry Print Report · For research reference only
Famciclovir → 9-[4-Acetoxy-3-(acetoxymethyl)but-1-yl]-2-amino-6,8-dichloropurine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Famciclovir | HCID 3324 | — |
| Reactant | 6,8-Dichloro-9H-purin-2-amine | HCID 5464677 | — |
| Product | 9-[4-Acetoxy-3-(acetoxymethyl)but-1-yl]-2-amino-6,8-dichloropurine | HCID 11025564 | — |
Reaction Steps
Moreover, U.S. Pat. No. 5,138,057 discloses a process for preparing 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine of Formula (I), in which 2-amino-6,8-dichloropurine of Formula (X) is reacted with 2-acetoxymethyl-4-halobut-1-yl-acetate of Formula (VII) to give 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-amino-6,8-dichloropurine of Formula (XI) which is then reduced under a pressurized condition in the presence of palladium, as shown in Scheme 3 below.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07041823B2 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-9366565ebc55455a8cd243320e61ab02 |
| Source note | uspto-grants-2006_05 |