Procaine → HCID 178464102, compound

HRID 1824466Notes

Reaction equation

HRID 1824466 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.[NH2:12][C:13]1[CH:28]=[CH:27][C:16]([C:17]([O:19][CH2:20][CH2:21][N:22]([CH2:25][CH3:26])[CH2:23][CH3:24])=[O:18])=[CH:15][CH:14]=1>C(O)CCC>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4]([NH:12][C:13]2[CH:28]=[CH:27][C:16]([C:17]([O:19][CH2:20][CH2:21][N:22]([CH2:25][CH3:26])[CH2:23][CH3:24])=[O:18])=[CH:15][CH:14]=2)[N:3]=1

Participants

4

Reactant 2

HCID 4914ProcaineHCID 53244122,6-Dichloropurine

Product 1

HCID 178464102HCID 178464102, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

The procedure is carried out as in Example 1, starting with 472.5 mg of 2,6-dichloropurine, 5 ml of butanol and 737.3 mg of 2-(N,N-diethylamino)ethyl 4-amino-benzoate. 972.2 mg of the expected product are thus obtained.

Sources & evidence

ORD record
ord-e04627f4a8ba4b05805e2e35498ca0fb
Source dataset
uspto-grants-2006_05
Patent number
US07041824B2

Reaction notes

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