p-Aminoacetophenone → HCID 178519696, compound

HRID 1824472Notes

Reaction equation

HRID 1824472 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.C[C:13]([C:15]1[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=1)=[O:14]>C(O)CCC>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4]([NH:21][C:18]2[CH:19]=[CH:20][C:15]([CH:13]=[O:14])=[CH:16][CH:17]=2)[N:3]=1

Participants

4

Reactant 2

HCID 7468p-AminoacetophenoneHCID 53244122,6-Dichloropurine

Product 1

HCID 178519696HCID 178519696, compoundYield 112.5%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

The procedure is carried out as in Example 1, starting with 189 mg of 2,6-dichloropurine, 5 ml of butanol and 149 mg of 4-aminoacetophenone. 308 mg of the expected product are thus obtained.

Sources & evidence

ORD record
ord-c5bb0f2aeede47deb606acc3f8eb78d7
Source dataset
uspto-grants-2006_05
Patent number
US07041824B2

Reaction notes

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