3-Nitroaniline → HCID 178469000, compound

HRID 1824477Notes

Reaction equation

Cl[C:2]1[NH:3][C:4]([NH:11][C:12]2[CH:22]=[CH:21][C:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:14][CH:13]=2)=[C:5]2[C:9]([N:10]=1)=[N:8][CH:7]=[N:6]2.[N+:23]([C:26]1[CH:27]=[C:28]([CH:30]=[CH:31][CH:32]=1)[NH2:29])([O-:25])=[O:24]>>[N+:23]([C:26]1[CH:27]=[C:28]([NH:29][C:2]2[N:10]=[C:9]3[C:5]([N:6]=[CH:7][NH:8]3)=[C:4]([NH:11][C:12]3[CH:22]=[CH:21][C:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:14][CH:13]=3)[N:3]=2)[CH:30]=[CH:31][CH:32]=1)([O-:25])=[O:24]

Participants

Reactant 2

HCID 74233-Nitroaniline

HCID 178469002HCID 178469002, compound

Product 1

HCID 178469000HCID 178469000, compoundYield 54.1%

Procedure

The procedure is carried out as in stage 2 of Example 1, using 238 mg of the product obtained in stage 1 of Example 1 and 520 mg of 3-nitroaniline in place of trans-1,4diaminocyclohexane. 170 mg of the expected product are thus obtained.

Sources & evidence

ORD record: ord-c0d10c2d05a246b893d54978ed9f6605
Source dataset: uspto-grants-2006_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07041824B2

Reaction notes

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