HCID 22149719, compound → HCID 22149717, compound

HRID 1824483Notes

Reaction equation

HRID 1824483 reaction equation
[CH3:1][CH:2]([CH3:13])[CH2:3][CH:4]([OH:12])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[F:11]>O=[Mn]=O>[CH2:3]([C:4]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[F:11])=[O:12])[CH:2]([CH3:13])[CH3:1]

Participants

3

Reactant 1

HCID 22149719HCID 22149719, compound

Product 1

HCID 22149717HCID 22149717, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 14801Manganese dioxideCatalyst

Procedure

In a round bottom flask (100 ml) was placed 3-methyl-1-(2-fluoro phenyl)butylalcohol 12 (1.85 gm, 0.0103 mole) and dichloromethae (35 ml). MnO2 (12.52 gm) was added to it. The reaction mixture was stirred for 20 hrs. After the completion of reaction (monitored by TLC or GC), the reaction mire was filtered through cilite, the filtrate was concentrated under reduced pressure to yield 1.57 gm (86%) of isobutyl-(2-fluoro-phenyl)-ketone 13 (GC purity 95%). 1HNMR CDCl3: (spectrum 12) 0.96(d, 6H), 2.30(m, 1H), 2.85(m, 2H), 7.15(m, 2H), 7.45(m, 1H), 7.85(m, 1H).

Workup

  1. customIn a round bottom flask (100 ml) was placed
  2. customAfter the completion of reaction (monitored by TLC or GC)
  3. filtrationthe reaction mire was filtered through cilite
  4. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-c1330d33204248759d9ab360fba73235
Source dataset
uspto-grants-2006_05
Patent number
US07041830B2

Reaction notes

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