反应详情

温度

10 °C

The product of Step B (0.135 g) in dichloromethane (3 mL) was treated with pyridine (0.37 g) and cooled to 10° C. The cold solution was treated with methanesulfonyl chloride (0.112 g) and allowed to stir and warm to ambient temperature over 18 hours. The reaction mixture was washed with 1% H2SO4 solution, saturated sodium bicarbonate solution, dried over magnesium sulfate, filtered and evaporated to give the title compound (0.115 g).

1. temperaturewarm to ambient temperature over 18 hours
2. washThe reaction mixture was washed with 1% H2SO4 solution, saturated sodium bicarbonate solution
3. dry with materialdried over magnesium sulfate
4. filtrationfiltered
5. customevaporated