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2-[4-[4-Hydroxybut-1-ynyl]phenyl]-7-methylimidazo[1,2-a]pyridine → 2-[4-[4-Hydroxybutyl]phenyl]-7-methylimidazo[1,2-a]pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-[4-[4-Hydroxybut-1-ynyl]phenyl]-7-methylimidazo[1,2-a]pyridine | HCID 22015594 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-[4-[4-Hydroxybutyl]phenyl]-7-methylimidazo[1,2-a]pyridine | HCID 22015655 | 92.6% |
反応手順
The product of Step B, Example 33 (0.3 g) in ethanol (15 mL) was hydrogenated over 5% palladium on barium sulfate (0.06 g) for 4.5 hours. The reaction mixture was filtered and evaporated to afford the title compound (0.282 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07041828B2 |
| 出典データセット | uspto-grants-2006_05 |
| ORD ID | ord-7dabd75f4f5445a89911f985c724bbc0 |
| 出典メモ | uspto-grants-2006_05 |