Pyridine → HCID 23572123, compound

HRID 1824572Notes

Reaction equation

HRID 1824572 reaction equation
[OH:1][CH2:2][C:3](=[CH2:17])[C:4]([O:6][CH:7]1[CH2:15][CH:14]2[CH2:16][CH:8]1[CH:9]1[CH:13]2[CH2:12][CH2:11][CH2:10]1)=[O:5].N1C=CC=CC=1.[C:24](OC(=O)C)(=[O:26])[CH3:25]>O>[C:24]([O:1][CH2:2][C:3](=[CH2:17])[C:4]([O:6][CH:7]1[CH2:15][CH:14]2[CH2:16][CH:8]1[CH:9]1[CH:13]2[CH2:12][CH2:11][CH2:10]1)=[O:5])(=[O:26])[CH3:25]

Participants

5

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 23572121HCID 23572121, compound

Product 1

HCID 23572123HCID 23572123, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a mixture of 23.6 g of 8-tricyclo[5.2.1.02,6]decyl α-(hydroxymethyl)acrylate and 15.8 g of pyridine was added 15.3 g of acetic anhydride. The mixture was stirred for 20 hours. Water was added to the reaction solution to stop the reaction, followed by conventional aqueous workup. The solvent was distilled off in vacuo. Purification by distillation (boiling point 123° C./13 Pa) gave 23.7 g (yield 90%) of 8-tricyclo[5.2.1.02,6]decyl α-(acetoxymethyl)acrylate represented by formula (12).

Workup

  1. customthe reaction
  2. distillationThe solvent was distilled off in vacuo
  3. customPurification
  4. distillationby distillation (boiling point 123° C./13 Pa)

Sources & evidence

ORD record
ord-12e7af10081a49a990e0313d4c2aff14
Source dataset
uspto-grants-2006_05
Patent number
US07041846B2

Reaction notes

Loading…