Stannous Chloride → HCID 10265481, compound

Participants

Reaction Steps

The authentic sample, N,N-dimethyl-2-(2-amino-4-fluorophenylthio)benzylamine (12) vas also synthesized in multisteps. Reaction of 2-chloro-5-fluoronitrobenzene with 2-thio-N,N-dimethylbenzamide gave N,N-dimethyl-2-(2-nitro-4-fluorophenylthio)-benzamide (9). Reduction of compound 9 with BH3 gave N,N-dimethyl-2-(2-nitro-4-fluorophenylthio)benzylamine (10) and its amine borane (11) in a ratio of ˜1:1 (Scheme 1). Compound 10 was reduced further with SnCl2 to give the final product (12).

Provenance & Evidence