N,N-Dimethyl-1,3-propanediamine → HCID 13491588, compound

HRID 1824648Notes

Reaction equation

HRID 1824648 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([O:11][CH3:12])[N:3]=1.[CH3:13][N:14]([CH3:19])[CH2:15][CH2:16][CH2:17][NH2:18]>C(O)C>[CH3:12][O:11][C:4]1[N:3]=[C:2]([NH:18][CH2:17][CH2:16][CH2:15][N:14]([CH3:19])[CH3:13])[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 7993N,N-Dimethyl-1,3-propanediamineHCID 27950292-Chloro-6-methoxy-3-nitropyridine

Product 1

HCID 13491588HCID 13491588, compoundYield 78.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4 g (0.0212 mol) of the product 2-chloro-3-nitro-6-methoxypyridine, 40 ml of ethanol and 5.33 ml (0.0424 mol) of 3-dimethylaminopropylamine are placed in a fully equipped round-bottomed flask. The mixture is refluxed for 2 hours with stirring and is then poured onto an ice/water mixture with stirring. The precipitate formed is filtered off by suction and dried under vacuum to constant weight. 4.2 g of yellow powder are obtained, ie a yield of 78.1%.

Workup

  1. temperatureThe mixture is refluxed for 2 hours
  2. stirringwith stirring
  3. customThe precipitate formed
  4. filtrationis filtered off by suction
  5. customdried under vacuum to constant weight

Sources & evidence

ORD record
ord-1f09b0b353c149bc92bf86d14aafacc5
Source dataset
uspto-grants-2006_05
Patent number
US07044987B2

Reaction notes

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