Pyridine → HCID 86585443, compound

Participants

Reaction Steps

To an oven-dried, septaed 10 mL round-bottom flask, cooled under an argon atmosphere, and charged with 25m (136.0 mg, 0.51 mmol) and 2-aminoethanethiol hydrochloride (57.8 mg, 0.51 mmol) were added 2 mL freshly distilled CH2Cl2 and anhydrous pyridine (82 μL, 1.02 mmol). The reaction immediately clouded then cleared after 30 minutes. The reaction was stirred for 3 hours at room temperature, then poured into water and extracted twice with CH2Cl2. The combined CH2Cl2 extracts were washed once with 5% aqueous HCl, once with 10% aqueous sodium bicarbonate, once with saturated brine, then once with water. The organic fraction was dried over anhydrous magnesium sulfate, filtered, and concentrated in vacuo to afford 123.0 mg (38% from 24m) of 26m as a colorless oil.

Provenance & Evidence