3-(Trifluoromethyl)phenol → 1-nitro-4-(3-(trifluoromethyl)phenoxy)benzene

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-chloro-4-nitrobenzene (11 g), 3-(trifluoromethyl)phenol (12 g), and potassium carbonate (21 g) in dimethyl formamide (175 mL) was heated at 120° C. for about 16 hours. The reaction mixture was cooled to room temperature and poured over ice-water. The mixture was filtered and the solid collected was washed with water and dried under vacuum (25 g).

Provenance & Evidence