Methanol → 5-Chloro-2-(1-homopiperazinyl)-7-methylbenzoxazole sulfate

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Reaction Steps

A solution of 5-chloro-2-(1-homopiperazinyl)-7-methylbenzoxazole (2.5 g) in ethyl acetate (75 mL) was added dropwise with a separately prepared sulfuric acid/methanol solution [prepared by adding methanol to 95% sulfuric acid (0.53 mL) to a total volume of 12.5 mL] at room temperature with stirring. The mixture was stirred for 1 hour with ice cooling, and the produced colorless precipitates were collected by filtration. The precipitates were dried at 35 C.° under reduced pressure for 5 hours to obtain the title compound (3.3 g).

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