1-Azabicyclo(2.2.2)octan-3-one, hydrochloride (1:1) → 3-Quinuclidinone

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Reaction Steps

3-Quinuclidinone hydrochloride (Aldrich, 16.1 g, 100 mol) was treated with saturated with NaHCO3 (20 mL) at ambient temperature for 10 minutes. It was then extracted with diethyl ether (4×100 mL). The extracts were combined, washed with brine (2×20 mL) and dried over MgSO4 (Aldrich, anhydrous). The drying reagents were removed by filtration and the filtrate was concentrated under reduced pressure at ambient temperature to give the title compound as white solid (11.0 g, 88% yield). MS (DCl/NH3) m/z 126 (M+H)+.

Provenance & Evidence