7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol → HCID 135430308, compound

Participants

Reaction Conditions

Reaction Steps

To 7-bromo-2-(4-hydroxy-phenyl)-benzooxazol-5-ol (96 mg) in DMF (3 mL) was added CuCN (84 mg). The mixture was placed in an oil bath and heated to 150° C. for 3 h. The mixture was cooled to room temperature and diluted with ethyl acetate and washed with 1N HCl, saturated aqueous EDTA, brine (3×), dried (Na2SO4), and concentrated. Flash chromatography on silica gel eluting with 20% ethyl acetate-hexane afforded 20 mg (25%) of the title compound as a solid. MS: 253 (MH+), HPLC tR: 2.06 min.

Provenance & Evidence