Tetrahydrofuran → HCID 22144527, compound

Participants

Reaction Steps

To a solution of 4-methylcarboxy-6-methoxy-2-(4-methoxy-phenyl)-benzothiazole (0.37 g, 1.12 mmol) in THF (6 mL) and water (3 mL) was added 1N sodium hydroxide (2.24 mL, 2.24 mmol) and the solution was stirred at room temperature for 24 h. THF was then evaporated. 1 N HCl was added to PH 1. The solid was collected by filtration and washed with water to give 4-carboxy-6-methoxy-2-(4-methoxy-phenyl)benzothiazole (0.29 g, 82% yield) as a white solid. Mass spec: MH+=316.

Provenance & Evidence