HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 21964517, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | HCID 9926783 | HCID 9926783 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 21964517 | HCID 21964517 | — |
Reaction Steps
To a solution of 4-(3-(2,6-Dimethylbenzyloxy)phenyl)-4-oxobutyric acid (Step D) in DMF, add triethylamine and BOP, after couple of hours of stirring, reaction mixture can be added to liquid ammonia at −40° C. and the resulting mixture can be warmed for 16 hours to give title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07045541B2 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-ec5de7193f6042438eeb4a0f9891ef66 |
| Source note | uspto-grants-2006_05 |