3-[4-(Z)-(1,2-diphenylbut-1-enyl)phenyl]-acrylic acid → HCID 86601470, compound

Participants

Reaction Steps

Prepared by coupling 1a and 2,2,2-trifluoroethanesulfonamide (Synlett, 1997, 375) in accordance with Procedure 1, Method A described hereinabove. Yield (34%); 1H NMR (d6-DMSO) δ 7.39–7.01 (m, 13H), 6.83 (d, J=8.1 Hz, 2H), 6.40 (d, J=15.7 Hz, 1H), 2.85 (s, 1H), 2.69 (s, 1H), 2.36 (q, J=7.3 Hz, 2H), 0.83 (t, J=7.3 Hz, 3H); ESI m/z: 498 (M−H−).

Provenance & Evidence