2-Thiophenesulfonamide → HCID 85337397, compound

HRID 1824896Notes

Reaction equation

HRID 1824896 reaction equation
[C:1]1(/[C:7](/[C:17]2[CH:22]=[CH:21][C:20]([CH:23]=[CH:24][C:25](O)=[O:26])=[CH:19][CH:18]=2)=[C:8](/[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)\[CH2:9][CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[S:28]1[CH:32]=[CH:31][CH:30]=[C:29]1[S:33]([NH2:36])(=[O:35])=[O:34]>>[C:1]1([C:7]([C:17]2[CH:22]=[CH:21][C:20]([CH:23]=[CH:24][C:25]([NH:36][S:33]([C:29]3[S:28][CH:32]=[CH:31][CH:30]=3)(=[O:35])=[O:34])=[O:26])=[CH:19][CH:18]=2)=[C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:9][CH3:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 728812-ThiophenesulfonamideHCID 30361523-[4-(Z)-(1,2-diphenylbut-1-enyl)phenyl]-acrylic acid

Product 1

HCID 85337397HCID 85337397, compound

Procedure

Prepared by coupling 1a and 2-thiophenesulfonamide (Synlett, 1997, 375) in accordance with Procedure 1, Method A described hereinabove. Yield (27%); 1H NMR (d6-DMSO) δ 12.34 (br s, 1H), 7.99 (m, 1H), 7.76 (m, 1H), 7.39–7.08 (m, 14H), 6.85 (d, J=8.4 Hz, 2H), 6.41 (d, J=15.7 Hz, 1H), 2.36 (q, J=7.3 Hz, 2H), 0.82 (t, J=7.3 Hz, 3H); APcI m/z: 500 (M+H+).

Workup

  1. customPrepared
  2. customYield (27%)

Sources & evidence

ORD record
ord-c2e0a45715814023a94e636f0b7dc120
Source dataset
uspto-grants-2006_05
Patent number
US07045540B2

Reaction notes

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