Methanesulfonamide → HCID 69320747, compound

HRID 1824905Notes

Reaction equation

HRID 1824905 reaction equation
[C:1]1([CH:7]2[CH2:16][CH2:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[CH:8]2[C:17]2[CH:22]=[CH:21][C:20]([CH:23]=[CH:24][C:25]([OH:27])=O)=[CH:19][CH:18]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:28][S:29]([NH2:32])(=[O:31])=[O:30]>>[C:1]1([CH:7]2[CH2:16][CH2:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[CH:8]2[C:17]2[CH:22]=[CH:21][C:20]([CH:23]=[CH:24][C:25]([NH:32][S:29]([CH3:28])(=[O:31])=[O:30])=[O:27])=[CH:19][CH:18]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 72879MethanesulfonamideHCID 69320774HCID 69320774, compound

Product 1

HCID 69320747HCID 69320747, compound

Procedure

Prepared by coupling 7d and methylsulfonamide in accordance with Procedure 1, Method A described hereinabove. Yield (56%); 1H NMR (CDCl3) δ 7.63 (d, J=15.4 Hz, 1H), 7.14 (m, 8H), 6.83 (m, 3H), 6.46 (d, J=8.1 Hz, 2H), 6.26 (d, J=15.4 Hz, 1H), 4.37 (d, J=5.1 Hz, 1H), 3.46 (m, 1H), 3.34 (s, 3H), 3.13 (m, 2H), 2.16 (m, 1H), 1.88 (m, 1H); ESI m/z: 430 (M−H−, 100%).

Workup

  1. customPrepared
  2. customYield (56%)

Sources & evidence

ORD record
ord-93c87430aa204739b978dedf4b6cf888
Source dataset
uspto-grants-2006_05
Patent number
US07045540B2

Reaction notes

Loading…