Sulfuric Acid → HCID 22144741, compound

Temperature

0 °C

A mixture of 90.4 gm (0.40 mole) 2-bromo-4-fluoro-5-chlorophenol (containing 10% 2-bromo-3-chloro-4-fluorophenol) and 64 gm (0.45 mole) hexamethylenetetramine was cooled in an ice bath. To this cooled mixture were added 306 mL trifluoroacetic acid. After stirring at about 0° C. for 15 minutes, the reaction mixture was heated at reflux for 1.5 hours. The reaction mixture was then cooled in an ice bath and treated with 439 mL of water followed by 220 mL 50% sulfuric acid. The reaction mixture was stirred without cooling for two hours. The reaction mixture was then diluted with 500 mL water and the resulting solid collected by filtration. The solid was washed with water until the wash was neutral (pH about 7). The solid was dried under reduced pressure and was then subjected to silica gel chromatography, eluting with a gradient of hexane containing from 0–2% ethyl acetate. Fractions containing the desired compound were combined and concentrated under reduced pressure to provide 57 gm (62%) 2-hydroxy-3-bromo-5-fluoro-6-chlorobenzaldehyde.

1. temperaturewas cooled in an ice bath
2. temperaturethe reaction mixture was heated
3. temperatureat reflux for 1.5 hours
4. temperatureThe reaction mixture was then cooled in an ice bath
5. stirringThe reaction mixture was stirred
6. temperaturewithout cooling for two hours
7. filtrationthe resulting solid collected by filtration
8. washThe solid was washed with water until the wash
9. customThe solid was dried under reduced pressure
10. washeluting with a gradient of hexane containing from 0–2% ethyl acetate
11. additionFractions containing the desired compound
12. concentrationconcentrated under reduced pressure

ORD record

ord-63695d0adba1414d85a1bb3914ab2621

Source dataset

uspto-grants-2006_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07045545B1