(2S)-3,3,3-Trifluoro-2-hydroxy-2-methylpropanoic acid → HCID 9820746, compound

HRID 1825Notes

Reaction equation

HRID 1825 reaction equation
[NH2:1][C:2]1[C:7]2[C:8](=[O:16])[C:9]3[S:15][CH:14]=[CH:13][C:10]=3[CH2:11][O:12][C:6]=2[CH:5]=[CH:4][CH:3]=1.[F:17][C:18]([F:26])([F:25])[C@:19]([OH:24])([CH3:23])[C:20](O)=[O:21]>>[F:17][C:18]([F:26])([F:25])[C@:19]([OH:24])([CH3:23])[C:20]([NH:1][C:2]1[C:7]2[C:8](=[O:16])[C:9]3[S:15][CH:14]=[CH:13][C:10]=3[CH2:11][O:12][C:6]=2[CH:5]=[CH:4][CH:3]=1)=[O:21]

Participants

3

Reactant 2

HCID 7019028(2S)-3,3,3-Trifluoro-2-hydroxy-2-methylpropanoic acidHCID 196930079-Amino-4,10-dihydrothieno[3,2-c][1]benzoxepin-10-one

Product 1

HCID 9820746HCID 9820746, compoundYield 35%

Procedure

Substantially the same procedure as in Example 1 was repeated using 9-amino-4,10-dihydrothieno[3,2-c][1]benzoxepin-10-one obtained in Reference Example 11 (0.840 g, 3.63 mmol) and (S)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid obtained in Reference Example 27 (1.14 g, 7.26 mmol) to give Compound 33 (0.47 g, 35%).

Sources & evidence

ORD record
ord-6484a284b0aa46eaae0c0af132625719
Source dataset
uspto-grants-1998_03
Patent number
US05726325

Reaction notes

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