HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1825045Generated: November 2, 2026
Tributylvinyltin → 2-Methoxy-7-vinyl-naphthalene
https://huagongshe.com/reaction/1825045
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tributylvinyltin | HCID 81998 | — |
| Reactant | Lithium Chloride | HCID 433294 | — |
| Reactant | Methanesulfonic acid, trifluoro-, 7-methoxy-2-naphthalenyl ester | HCID 10892112 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Product | 2-Methoxy-7-vinyl-naphthalene | HCID 22144967 | 97.8% |
Reaction Steps
To a mixture of (Ph3P)2PdCl2 (1.752 g), LiCl (6.36 g), and trifluoromethanesulfonic acid 7-methoxy-naphthalen-2-yl ester (15.3 g) was added dropwise tributyl(vinyl)tin (19.02 g). The resulting mixture was stirred over 4 h at 90° C. The reaction was quenched with water and extracted with CH2Cl2. The organic layer was washed with water and dried over MgSO4. After concentration, the crude product was purified by flash chromatography eluting with 20% ethyl acetate in hexanes to give the title compound as an oil (9 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07045551B2 |
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| Source dataset | uspto-grants-2006_05 |
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| ORD ID | ord-ef4095385e1d466d89f26722f924be1f |
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| Source note | uspto-grants-2006_05 |
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