1,2-Dichloroethane → HCID 69593474, compound

Participants

Reaction Steps

Mixture of (R)-2-Amino-2-(3-morpholin-4-yl-phenyl)-ethanol hydrochloride (70 mg, 0.24 mmol), cinnamic acid (35 mg, 0.24 mmol), EDC (91 mg, 0.47 mmol), DMAP (29 mg, 0.24 mmol), triethyl amine (0.13 mL, 0.95 mmol) in dichloromethane (1 mL) was stirred at room temperature overnight. The reaction mixture was concentrated under vacuum and purified by flash chromatography with 60% acetone/hexanes to provide the title compound as a white solid (57 mg, 68% yield).

Provenance & Evidence