Cesium carbonate → 6-[2-(3-Hydroxy-pyrrolidine-1-carbonyl)-thieno[3,2-b]pyridin-7-yloxy]-2-methyl-1H-indole-3-carboxylic acid methylamide

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Reaction Steps

This material was prepared by the reaction of 7-chloro-2-[(R)-3-hydroxypyrrolidine-1-carbynyl]thieno[3,2-b]pyridine 4a with 6-hydroxy-2-methyl-1H-indol-3-carboxylic acid methylamide and Cs2CO3 in a manner as previously described for Example 1. 1H NMR (300 MHz, CD3OD) δ 8.48 (1H, d, J=5.5 Hz), 7.91 (1H, d, J=17.3 Hz), 7.86 (1H, d, J=8.6 Hz), 7.21 (1H, s), 7.00 (1H, d, J=8.6 Hz), 6.69 (1H, d, J=5.5 Hz), 4.50 (1H, m), 4.05–3.70 (4H, m), 2.97 (3H, s), 2.63 (3H, s), 2.40–1.90 (2H, m). LCMS (ESI+) [M+H]/z Calc'd 451. found 451.

Provenance & Evidence