HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl ((1-benzylpyrrolidin-3-yl)methyl)carbamate → tert-butyl N-((pyrrolidin-3-yl)methyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl ((1-benzylpyrrolidin-3-yl)methyl)carbamate | HCID 5108694 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | tert-butyl N-((pyrrolidin-3-yl)methyl)carbamate | HCID 4250767 | 90.4% |
Reaction Steps
To a solution of tert-butyl (1-benzylpyrrolidin-3-yl)methylcarbamate (3.0 g, 10.33 mmole) in EtOAc (100 ml) was added Pd(OH)2 on carbon (0.3 g). The mixture was stirred under H2 balloon at room temperature for 3 h and filtered through Celite. The filtrate was concentrated to give colorless oil (1.87 g, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07045528B2 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-3f576d1bac4e4d91974b0feb7f731ae7 |
| Source note | uspto-grants-2006_05 |