HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-1-propanol → 6-Methoxy-1,2-dimethyl-1H-indole-3-carboxylic acid (3-hydroxy-propyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-1-propanol | HCID 9086 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 6-methoxy-1,2-dimethyl-1H-indole-3-carboxylic acid methylamide | HCID 20767869 | — |
| Reactant | 1,2-dimethyl-6-methoxy1H-indole-3-carboxylic acid | HCID 22143494 | — |
| Product | 6-Methoxy-1,2-dimethyl-1H-indole-3-carboxylic acid (3-hydroxy-propyl)-amide | HCID 20767901 | — |
Reaction Steps
This material was prepared by the reaction of 1,2-dimethyl-6-methoxy-1H-indole-3-carboxylic acid 16c with 3-hydroxy-propyl amine and oxalyl chloride in a manner as previously described for 16d. 1H NMR (300 MHz, CD3OD) δ 7.52 (1H, d, J=8.6 Hz), 6.73 (1H, d, J=2.1 Hz), 6.68 (1H, dd, J=2.1, 8.6 Hz), 3.69 (2H, t, J=6.1 Hz), 3.79 (3H, s), 3.63 (3H, s), 3.51 (2H, m), 2.57 (3H, s), 1.85 (2H, m). LCMS (ESI+) [M+H]/z Calc'd 291. found 291.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07045528B2 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-0f391a5c83c742feb8f53a343434bc76 |
| Source note | uspto-grants-2006_05 |