反应详情

This material was prepared by the reaction of (7-chloro-thieno[3,2-b]-pyridin-2-yl)-((R)-3-hydroxy-pyrrolidin-1-yl)-methanone 4a with 6-hydroxy-1,2-dimethyl-1H-indole-3-carboxylic acid (3-hydroxy-propyl)-amide 63b and Cs2CO3 in a manner as previously described for example 1. 1H NMR (300 MHz, CD3OD) δ 8.38 (1H, d, J=5.5 Hz), 7.84–7.74 (2H,m), 7.28 (1H, d, J=2.1 Hz), 6.94 (1H, dd, J=2.1, 8.6 Hz), 6.60 (1H, d, J=5.5 Hz), 4.45–4.42 (1H, m), 3.93–3.91 (2H, m), 3.71–3.60 (8H, m), 3.45 (2H, m), 2.56 (3H, s), 2.02–1.98 (2H, m), 1.72–1.68 (2H, m). LCMS (ESI+) [M+H]/z Calc'd 509. found 509.