HRID1825181

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10796

Cesium carbonate

CCs2O3

结构：COC[C@@H]1CCCN1C(=O)c1cc2nccc(Cl)c2s1

HCID20767764

未命名化合物

HCID20767865

未命名化合物

PRODUCTS

生成物

结构：COCC1CCCN1C(=O)c1cc2nccc(Oc3ccc4c(C(=O)NCC(C)C)c(C)oc4c3)c2s1

HCID20767925

未命名化合物

PROCEDURE

实验过程

This material was prepared by the reaction of 7-chloro-2-[(R)-2-methoxymethylpyrrolidine-1-carbonyl]thieno[3,2-b]pyridine 2a with 6-hydroxy-2-methyl-benzofuran-3-carboxylic acid isobutyl amide 84b and Cs2CO3 in a manner as previously described for example 1. 1H NMR (CD3CN) δ 8.53 (1H,d, J=5.3 Hz), 7.87 (1H, s), 7.82 (1H, d, J=8.5 Hz), 7.41 (1H, d, J=1.9 Hz), 7.20 (1H, dd, J=8.5, 1.9 Hz), 6.70 (1H, d, J=5.5 Hz), 4.38 (1H, m), 3.85 (2H, m), 3.65–3.41 (2H, m), 3.32 (3H, s), 3.23 (2H, t, J=6.4 Hz), 2.65 (3H, s), 2.15–1.94 (4H,m, partially obscured by CD3CN), 1.73 (1H, m),

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7c84e96a2ae246bc80ff5a917af77a32
来源数据集: uspto-grants-2006_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07045528B2
来源说明: uspto-grants-2006_05

反应 SMILES

Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[CH:8]=[C:9]([C:11]([N:13]3[CH2:17][CH2:16][CH2:15][C@H:14]3[CH2:18][O:19][CH3:20])=[O:12])[S:10][C:3]=12.[CH2:21]([NH:25][C:26]([C:28]1[C:32]2[CH:33]=[CH:34][C:35]([OH:37])=[CH:36][C:31]=2[O:30][C:29]=1[CH3:38])=[O:27])[CH:22]([CH3:24])[CH3:23].C([O-])([O-])=O.[Cs+].[Cs+]>>[CH2:21]([NH:25][C:26]([C:28]1[C:32]2[CH:33]=[CH:34][C:35]([O:37][C:2]3[CH:7]=[CH:6][N:5]=[C:4]4[CH:8]=[C:9]([C:11]([N:13]5[CH2:17][CH2:16][CH2:15][CH:14]5[CH2:18][O:19][CH3:20])=[O:12])[S:10][C:3]=34)=[CH:36][C:31]=2[O:30][C:29]=1[CH3:38])=[O:27])[CH:22]([CH3:24])[CH3:23]