Cesium carbonate → 2-Methyl-6-[2-(3-methoxy-pyrrolidine-1-carbonyl)-thieno[3,2-b]pyridin-7-yloxy]-benzofuran-3-carboxylic acid isobutyl amide

Participants

Reaction Steps

This material was prepared by the reaction of 7-chloro-2-[(R)-3-methoxypyrrolidine-1-carbonyl]thieno[3,2-b]pyridine 4b with 6-hydroxy-2-methyl-benzofuran-3-carboxylic acid isobutyl amide 83b and Cs2CO3 in a manner as previously described for example 1. 1H NMR (CD3CN) δ 8.53 (1H,d, J=5.5 Hz), 7.88 (1H, d, J=3.0 Hz), 7.82 (1H, d, J=8.5 Hz), 7.41 (1H, d, J=2.3 Hz), 7.20 (1H, dd, J=8.5, 2.3 Hz), 6.70 (2H, d, J=5.5 Hz), 4.10–3.83 (3H, m), 3.73–3.58 (2H, m), 3.33, 3.29 (3H, 25), 3.23 (2H, t, J=6.8 Hz), 2.65 (3H, s), 2.10–1.95 (2H,m), 0.98 (6H, d, J=6.6 Hz).

Provenance & Evidence