Butylamine → 2-Methyl-6-[Thieno(3,2-b)pyridin-7-yloxy]benzofuran-3-carboxylic acid butyl amide
Reaction equation
[CH3:1][C:2]1[O:3][C:4]2[CH:13]=[C:12]([O:14][C:15]3[CH:20]=[CH:19][N:18]=[C:17]4[CH:21]=[CH:22][S:23][C:16]=34)[CH:11]=[CH:10][C:5]=2[C:6]=1[C:7](O)=[O:8].[CH2:24]([NH2:28])[CH2:25][CH2:26][CH3:27]>>[CH2:24]([NH:28][C:7]([C:6]1[C:5]2[CH:10]=[CH:11][C:12]([O:14][C:15]3[CH:20]=[CH:19][N:18]=[C:17]4[CH:21]=[CH:22][S:23][C:16]=34)=[CH:13][C:4]=2[O:3][C:2]=1[CH3:1])=[O:8])[CH2:25][CH2:26][CH3:27]Participants
3
Procedure
This material was prepared from 2-methyl-6-[thieno[3,2-b]pyridin-7-yloxy]benzofuran-3-carboxylic acid 100 and butylamine in a similar manner as that described for example 102. 1H NMR (CD3CN) δ 8.48 (1H,d, J=5.3 Hz), 7.91 (1H, d, J=5.6 Hz), 7.81 (1H, d, J=8.6 Hz), 7.53 (1H, d, J=5.6 Hz), 7.41 (1H, d, J=2.3 Hz), 7.20 (1H, dd, J=8.6, 2.3 Hz), 6.62 (1H, d, J=5.3 Hz), 6.62 (1H, bm), 3.40 (2H, q, J=6.9 Hz), 2.65 (3H, s), 1.60 (2H, m), 1.42 (2H, m), 0.97 (3H, t, J=7.3 Hz).
Sources & evidence
- ORD record
- ord-b0519cd70cf14831ac9b04e8b80f685f
- Source dataset
- uspto-grants-2006_05
- Patent number
- US07045528B2
Reaction notes
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