1H-Pyrazol-3-amine, 5-methyl- → HCID 20767811, compound

HRID 1825201Notes

Reaction equation

HRID 1825201 reaction equation
[CH3:1][C:2]1[O:3][C:4]2[CH:13]=[C:12]([O:14][C:15]3[CH:20]=[CH:19][N:18]=[C:17]4[CH:21]=[CH:22][S:23][C:16]=34)[CH:11]=[CH:10][C:5]=2[C:6]=1[C:7](Cl)=[O:8].[CH3:24][C:25]1[NH:29][N:28]=[C:27]([NH2:30])[CH:26]=1>>[CH3:24][C:25]1[NH:29][N:28]=[C:27]([NH:30][C:7]([C:6]2[C:5]3[CH:10]=[CH:11][C:12]([O:14][C:15]4[CH:20]=[CH:19][N:18]=[C:17]5[CH:21]=[CH:22][S:23][C:16]=45)=[CH:13][C:4]=3[O:3][C:2]=2[CH3:1])=[O:8])[CH:26]=1

Participants

3

Reactant 2

HCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 221434802-Methyl-6-[thieno[3,2-b]pyridin-7-yloxy]benzofuran-3-carbonyl chloride

Product 1

HCID 20767811HCID 20767811, compound

Procedure

This material was prepared from 2-methyl-6-[thieno[3,2-b]pyridin-7-yloxy]benzofuran-3-carbonyl chloride 101 and (5-methyl-1H-pyrazol-3-yl)amine in a similar manner as that described for example 108. 1H NMR (DMSO-d6) δ 12.09 (1H, bs), 10.45 (1H, s), 8.50 (1H, d, J=5.6 Hz), 8.14 (1H, d, J=5.6 Hz), 7.77 (1H, d, J=8.6 Hz), 7.65 (1H, d, J=2.3 Hz), 7.59 (1H, d, J=5.3 Hz), 7.24 (1H, dd, J=8.3, 2.0 Hz), 6.64 (1H, d, J=5.6 Hz), 6.39 (1H, bs), 2.64 (3H, s), 2.23 (3H, s).

Sources & evidence

ORD record
ord-a231426d34fa414aa65dfd34b0ea5b5e
Source dataset
uspto-grants-2006_05
Patent number
US07045528B2

Reaction notes

Loading…