HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-Chlorobenzenepropanoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-(2-Chlorophenyl)propanoic acid | HCID 95676 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-Chlorobenzenepropanoyl chloride | HCID 15122576 | — |
Reaction Steps
A mixture of 3-(2-chlorophenyl)propanoic acid (5.0 g, 27.1 mmole), thionyl chloride (10.9 ml, 149 mmole) and toluene (75 ml) was refluxed for two hours. Concentration in vacuo gave 3-(2-chlorophenyl)propanoyl chloride which was taken up in methylene chloride and used in the next step without further purification. Step 2:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07045591B2 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-c5e0398a606d4a6ebe2e4c77e23bbf95 |
| Source note | uspto-grants-2006_05 |