Thionyl Chloride → HCID 22145249, compound

HRID 1825275Notes

Reaction equation

HRID 1825275 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][CH2:11][C:12]([OH:14])=O)([CH3:3])[CH3:2].S(Cl)([Cl:17])=O>C1(C)C=CC=CC=1>[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][CH2:11][C:12]([Cl:17])=[O:14])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 22145294HCID 22145294, compound

Product 1

HCID 22145249HCID 22145249, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 3-(2-isopropylphenyl)propanoic acid (prepared in 3 steps from 1-isopropyl-2-iodobenzene, 2.01 g, 10.5 mmole), thionyl chloride (4.30 ml, 59.0 mmole) and toluene (40 ml) was refluxed for 2 hours. Concentration in vacuo gave 3-(2-isopropylphenyl)propanoyl chloride which was taken up in methylene chloride and used in the next step as a crude. Step 2:

Workup

  1. temperaturewas refluxed for 2 hours
  2. concentrationConcentration in vacuo

Sources & evidence

ORD record
ord-abc4906ef1c8444ea454eb93bdf94b88
Source dataset
uspto-grants-2006_05
Patent number
US07045591B2

Reaction notes

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