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HRID1825307

反应详情

EQUATION

反应方程式

HRID 1825307 的结构方程式

REACTANTS

反应物

2
结构：C#CCCOCCCCCCNCc1ccccc1
HCID22145668

N-Benzyl-6-[(but-3-yn-1-yl)oxy]hexan-1-amine

C17H25NO

结构：O=CN(OCc1ccccc1)c1cccc([C@@H]2CO2)c1
HCID86760081

未命名化合物

PRODUCTS

生成物

1
结构：C#CCCOCCCCCCN(Cc1ccccc1)C[C@H](O)c1ccc(OCc2ccccc2)c(NC=O)c1
HCID11443930

未命名化合物

收率 159.6%

PROCEDURE

实验过程

A stirred mixture of 2-(benzyloxy-5-[(2R)-oxiran-2-yl]phenylformamide (R Hett et al, Organic Process Research & Development, 1998, 2, 96-99) (8.6 g) and N-benzyl-6-(but-3-ynyloxy)hexan-1-amine (9.1 g) was heated at 120° for 2 h. The mixture was purified by chromatography (Merck 9385) eluting with cyclohexane/ethyl acetate (2:1) to give the title compound (13.47 g). LCMS RT=2.68 min.

WORKUP

后处理

  1. temperaturewas heated at 120° for 2 h
  2. customThe mixture was purified by chromatography (Merck 9385)
  3. washeluting with cyclohexane/ethyl acetate (2:1)