HCID 58633500, compound → HCID 58633548, compound

Participants

Reaction Steps

A solution of the ethyl ester from example 17 (70 mg, 0.16 mmol) in sodium hydroxide solution (1 ml, 1N) and methanol (5 ml) was stirred at room temperature for 18 hours. The reaction was concentrated under reduced pressure to remove the methanol, and the residue was partitioned between ethyl acetate (10 ml) and hydrochloric acid (2N, 10 ml). The phases were separated, the aqueous layer extracted with ethyl acetate (4×10 ml), the combined organic solutions washed with brine (10 ml), dried (MgSO4) and evaporated under reduced pressure to afford the title compound, 50 mg; 1H NMR (CDCl3, 400 MHz) δ: 0.92 (t, 3H), 1.23–2.39 (m, 15H), 2.74 (d, 2H), 3.60 (m, 2H), 4.52 (m, 3H), 6.66 (d, 1H), 7.35 (m, 5H); HRMS: m/z (ES+) 420.2374 [MH+]; C23H33NO6 calculated 420.2381.

Provenance & Evidence