HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Hydrazinoethanol → Ethyl 1-(2-hydroxyethyl)-5-methylpyrazole-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Hydrazinoethanol | HCID 8017 | — |
| Reactant | Ethyl 2,4-dioxovalerate | HCID 69208 | — |
| Reactant | 1,5-Diethyl-1H-pyrazole-3-carboxylic acid | HCID 22145375 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 1-(2-hydroxyethyl)-5-methylpyrazole-3-carboxylate | HCID 22145424 | — |
Reaction Steps
The title compound was prepared from hydroxyethyl hydrazine (3.64 g, 50 mM) and ethyl 2,4-dioxovalerate (8.5 g, 50 mM) as described in Example 1 Preparation 1 as a colourless oil (9.39 g, 95%); νmax (CH2Cl2) 1700 cm−1; δH(CDCl3) 1.39 (3H, t, J7 Hz), 2.40 (3H, s), 2.98 (2H, t, J7 Hz), 4.33-4.48 (4H, m), and 6.39 (1H, s); E.I. m/e 198 (95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07045619B2 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-d031f63a2e17420490bb4b84c816b0cf |
| Source note | uspto-grants-2006_05 |