Acetic Anhydride → HCID 22145882, compound

HRID 1825412Notes

Reaction equation

HRID 1825412 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH3:12])[N+:6]([O-])=[N:7][C:8]=1[O:9][CH3:10].[C:13]([O:16]C(=O)C)(=[O:15])[CH3:14]>O>[C:13]([O:16][CH2:12][C:5]1[N:6]=[N:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=1)(=[O:15])[CH3:14]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 21766149HCID 21766149, compound

Product 1

HCID 22145882HCID 22145882, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 5,6-dimethoxy-3-methylpyridazine-2-oxide (0.5 g) in acetic anhydride (2 mL) is refluxed for 2 hours. After cooling the mixture is diluted with water and extracted with ethyl acetate (2×20 mL). The extracts are dried (MgSO4) and evaporated to give a brown oil which is purified by flash chromatography (ethyl acetate as eluent on silica) to give 6-acetoxymethyl-3,4-dimethoxypyridazine (0.27 g) as a colourless oil.

Workup

  1. temperatureis refluxed for 2 hours
  2. temperatureAfter cooling the mixture
  3. extractionextracted with ethyl acetate (2×20 mL)
  4. dry with materialThe extracts are dried (MgSO4)
  5. customevaporated
  6. customto give a brown oil which
  7. customis purified by flash chromatography (ethyl acetate as eluent on silica)

Sources & evidence

ORD record
ord-f2cb3852a7974dfd85b138a866185284
Source dataset
uspto-grants-2006_05
Patent number
US07045660B2

Reaction notes

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