4-Chlorobenzoyl chloride → HCID 22142737, compound

HRID 1825569Notes

Reaction equation

ClC1C=CC(C(Cl)=O)=CC=1.Cl[C:12]1[CH:17]=[CH:16][C:15]([C:18]#[N:19])=[CH:14][N:13]=1.Cl[C:21]1[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][C:22]=1[C:28]1[C:33]([C:34]2[NH:35][CH:36]=[CH:37][N:38]=2)=[CH:32][N:31]=[C:30]([NH:39][CH2:40][CH2:41][NH:42]C2C=CC([N+]([O-])=O)=CN=2)[N:29]=1>>[Cl:27][C:25]1[CH:24]=[CH:23][C:22]([C:28]2[C:33]([C:34]3[NH:38][CH:37]=[CH:36][N:35]=3)=[CH:32][N:31]=[C:30]([NH:39][CH2:40][CH2:41][NH:42][C:12]3[N:13]=[CH:14][C:15]([C:18]#[N:19])=[CH:16][CH:17]=3)[N:29]=2)=[CH:21][CH:26]=1

Participants

Reactant 3

HCID 85014-Chlorobenzoyl chloride

HCID 51520946-Chloro-3-pyridinecarbonitrile

HCID 9847557Chir-98023

Product 1

HCID 22142737HCID 22142737, compound

Procedure

6-[(2-{[4-(4-chlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]amino}ethyl)amino]pyridine-3-carbonitrile was prepared from 4-chlorobenzoyl chloride and 2-chloro-5-(cyano)pyridine using the general method for [4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine.

Sources & evidence

ORD record: ord-960fd1d6b5c54ccf88e017e8c8c56790
Source dataset: uspto-grants-2006_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07045519B2

Reaction notes

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