2-Nitrobenzenesulfonyl chloride → {2-[(5-Nitro(2-pyridyl))amino]ethyl}[(2-nitrophenyl)sulfonyl]amine

Participants

Role	Name	HCID	Charge
Reactant	2-Nitrobenzenesulfonyl chloride	HCID 15540	—
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	2-(2-Aminoethylamino)-5-nitropyridine	HCID 122425	—
Solvent	Dichloromethane	HCID 6344	—
Product	{2-[(5-Nitro(2-pyridyl))amino]ethyl}[(2-nitrophenyl)sulfonyl]amine	HCID 22142870	—

Reaction Conditions

Temperature	23 °C

Reaction Steps

To a suspension of resin-bound (2aminoethyl)(5-nitro(2-pyridyl))amine (30 g, 21 mmol), CH2Cl2 (250 mL) and iPr2NEt (18.3 mL, 105 mmol) at 23° C. was added 2-nitrobenzenesulfonyl chloride (23.3 g, 105 mmol). The resulting mixture was shaken at 23° C. for 6 h, filtered, washed with NMP, H2O and CH2Cl2 and air dried to yield polymer-bound {2-[(5-nitro(2-pyridyl))amino]ethyl}[(2-nitrophenyl)sulfonyl]amine.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07045519B2
Source dataset	uspto-grants-2006_05
ORD ID	ord-37694ae21c1046c9a1c0ff0b1315938c
Source note	uspto-grants-2006_05