HCID 22184641, compound → HCID 23533352, compound

HRID 1825666Notes

Reaction equation

HRID 1825666 reaction equation
[CH3:1][N:2]1CCN(C2C=CC3C(C=2)=CC=C2C=3OC(C(NC3C=CC(N4CCOCC4)=CC=3)=O)=CC2=O)CC1.C(O[C:41]1[CH:46]=[C:45]([N:47]2[CH2:52][CH2:51][O:50][CH2:49][CH2:48]2)[C:44](OCC)=[CH:43][C:42]=1[NH:56][C:57]([C:59]1[O:60][C:61]2[C:66]([C:67](=[O:69])[CH:68]=1)=[CH:65][CH:64]=[CH:63][C:62]=2[N:70]1[CH2:75][CH2:74][N:73]([CH3:76])[CH2:72][CH2:71]1)=[O:58])C>>[C:1]([C:44]1[CH:43]=[C:42]([NH:56][C:57]([C:59]2[O:60][C:61]3[C:66]([C:67](=[O:69])[CH:68]=2)=[CH:65][CH:64]=[CH:63][C:62]=3[N:70]2[CH2:75][CH2:74][N:73]([CH3:76])[CH2:72][CH2:71]2)=[O:58])[CH:41]=[CH:46][C:45]=1[N:47]1[CH2:48][CH2:49][O:50][CH2:51][CH2:52]1)#[N:2]

Participants

3

Reactant 2

HCID 22184641HCID 22184641, compoundHCID 69272428HCID 69272428, compound

Product 1

HCID 23533352HCID 23533352, compound

Procedure

This compound was prepared from 8-(4-Methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid hydrochloride (Reference Example 1) and 5-amino-2-morpholin-4-yl-benzonitrile (Reference Example 15) as prepared in Example 12, yielding a yellow solid. (120 mg=82%), LCMS−m/z=474.5

Workup

  1. customas prepared in Example 12
  2. customyielding a yellow solid

Sources & evidence

ORD record
ord-0d8d8648fbdb478594233f1bc27c4abc
Source dataset
uspto-grants-2006_05
Patent number
US07045514B2

Reaction notes

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