Ethanol hexane → HCID 49836387, compound

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Reaction Steps

The (3R)- and (3S)-diastereomers of (1S)-3-(3-dimethylaminocyclopentyl)-1H-indole-5-carbonitrile were resolved by chiral HPLC on a Chiral Technologies Chiralpak AD column (20μ, 50×500 mm) with a mobile phase of 10% ethanol in hexane-0.1% diethylamine at a flow rate of 75 mL/min. Analytical HPLC retention times refer to the following analytical chiral HPLC method: Chiralpak AD column, 4.6×250 mm with 10 μm packing. Solvents: 10% Ethanol/hexane (0.10% diethyl amine added in hexane as modifier). Flow: 1 mL/min for 20 min. UV detector at 280 nm. Loop volume: 20 μL. Injection load: 20 μL of a 1 mg/mL solution in ethanol.

Provenance & Evidence