Water → HCID 57198983, compound

Participants

Reaction Conditions

Reaction Steps

Sodium methoxide (0.28 g, 5.2 mmol) was added in one portion to a solution of 7-methyl-2H-1,4-benzothiazin-3(4H)-one (0.72 g, 4.0 mmol) and indole-3-carboxaldehyde (0.88 g, 6.0 mmol) in dry DMF (4 mL). The mixture was heated for 48 h at 140° C., allowed to cool, then poured into water (60 ml). The precipitate was collected by filtration and washed with water. The precipitate was then refluxed with toluene (100 ml) and filtered hot to give a yellow solid which was purified by silica gel chromatography using a gradient of (100:1) to (100:20) toluene:ethanol as the mobile phase.

Provenance & Evidence