1-Hydroxybenzotriazole → HCID 69584746, compound

Participants

Reaction Steps

Using General Procedure C, (±)-trans-(2-aminocyclopentyl)-[3-(4-chloro-phenyl)propyl]carbamic acid tert-butyl ester (155 mg, 0.44 mmol) and 4-methanesulfonylbenzoic acid (105 mg, 0.53 mmol) were coupled in CH2Cl2 (3 mL) using HOBt (12 mg, 0.09 mmol) and DEC (106 mg, 0.66 mmol) at 0° C. for 2.5 hours to give 250 mg of (±)-trans-[3-(4-chlorophenyl)propyl]-[2-(4-methanesulfonylbenzoylamino)cyclopentyl]carbamic acid tert-butyl ester as a colorless oil.

Provenance & Evidence