4-Phenoxyphenyl isocyanate → N-(4-phenoxyphenyl)-N'-[2-(2-pyrrolidin-1-ylethyl)-2H-indazol-5-yl]urea

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(2-pyrrolidin-1-yl-ethyl)-2H-indazol-5-ylamine (0.100 g, 0.434 mmol), 4-phenoxyphenyl isocyanate (0.0917 g, 0.434 mmol) and 6 mL of THF was stirred at 50° C. for 1 hour. The mixture was cooled to room temperature and the solvents removed under vacuo. The resultant solid was triturated in ether and collected by filtration to provide the titled product. 1H NMR (300 MHz, DMSO-D6) δ ppm 1.66 (m, 4 H), 2.50 (m, 4 H), 2.96 (m, 2 H), 4.48 (t, J=5.93 Hz, 2 H), 6.97 (m, 4 H), 7.11 (m, 2 H), 7.36 (m, 2 H), 7.50 (m, 3 H), 7.88 (m, 1 H), 8.26 (s, 1 H), 8.54 (s, 1 H), 8.64 (s, 1 H); MS (DCI/NH3) m/z 441 [M+H]+.

Provenance & Evidence