HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → Ngx-267
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-Ethyl-2-piperidinone | HCID 179570 | — |
| Reactant | HCID 11528611 | HCID 11528611 | — |
| Reactant | 2-MERCAPTOBUTYRIC ACID | HCID 11557278 | — |
| Product | Ngx-267 | HCID 10013505 | — |
Reaction Steps
There is also provided in accordance with an embodiment of the invention a process for the preparation of 2-ethyl-8-methyl-1-thia-4,8-diaza-spiro[4.5]decan-3-one (AF267), comprising reacting 4-ethyl piperidone with 2-mercaptobutyric acid and ammonia. In an embodiment of the invention, the process further comprising obtaining the enantiomers AF267A (R-enantiomer) and AF267B (S-enantiomer) by chiral separation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07049321B2 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-7ecdbe6d091146d0a644c7fcd6848c42 |
| Source note | uspto-grants-2006_05 |