AF 267B → HCID 11694209, compound

HRID 1825845Notes

Reaction equation

HRID 1825845 reaction equation
[CH3:1][CH2:2][C@@H:3]1[S:8][C:7]2([CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]2)[NH:6][C:4]1=[O:5]>C1CCCCC1>[CH2:2]([C@@H:3]1[C:4](=[O:5])[NH:6][C:7]2([CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]2)[S:8]1)[CH3:1]

Participants

3

Reactant 1

HCID 10013505AF 267B

Product 1

HCID 11694209HCID 11694209, compound

Reagents, catalysts & solvents 1

HCID 8078CyclohexaneSolvent

Procedure

The obtained (R)-2-mercaptobutyric acid was purified by distillation and then reacted with ammonium acetate and 1-methyl-4-piperidone in boiling cyclohexane. The crude reaction mixture was analyzed by GC on a chiral column and found to contain AF267A accompanied by a small (2–3%) amount of AF267B.

Workup

  1. distillationThe obtained (R)-2-mercaptobutyric acid was purified by distillation
  2. customreacted with ammonium acetate and 1-methyl-4-piperidone
  3. customThe crude reaction mixture

Sources & evidence

ORD record
ord-48e22892c0c84f428ffb971ff5eac8e7
Source dataset
uspto-grants-2006_05
Patent number
US07049321B2

Reaction notes

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