참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethylenediamine monohydrate | HCID 12200817 | — |
| 반응물 | 5-Bromo-6-methoxy-2-methylthioquinoline | HCID 22139696 | — |
| 반응물 | HCID 178418546 | HCID 178418546 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-Cyano-6-methoxy-2-methylthioquinoline | HCID 22139683 | 87% |
반응 단계
A mixture of 5-bromo-6-methoxy-2-methylthioquinoline (6.1 g, 21 mmol) and CuCN (3.7 g, 41 mmol) in DMF (80 mL) was heated at 150° C. for 14 hours. The mixture was cooled and treated sequentially with 2:1 H2O/ethylenediamine (15 mL). The mixture was extracted with 1:1 EtOAc/hexane. The organic layer was worked-up. HPLC (1:8 EtOAc/hexane) gave 4.2 g (87%) of 5-cyano-6-methoxy-2-methylthioquinoline as a light yellow solid, (M+) 230(100).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07049325B2 |
|---|
| 출처 데이터셋 | uspto-grants-2006_05 |
|---|
| ORD ID | ord-2f18635a9b434c60b6b6ce07a7900912 |
|---|
| 출처 메모 | uspto-grants-2006_05 |
|---|
