HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
5-(2,4-Difluoro-phenylsulfanyl)-2-methanesulfonyl-6-methoxy-quinoline → 5-(2,4-Difluoro-benzenesulfinyl)-2-methanesulfonyl-6-methoxy-quinoline
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 5-(2,4-Difluoro-phenylsulfanyl)-2-methanesulfonyl-6-methoxy-quinoline | HCID 9864712 | — |
| Edukt | Potassium hydroxy sulfite | HCID 23707502 | — |
| Lösungsmittel | Methanol tetrahydrofuran water | HCID 21892291 | — |
| Produkt | 5-(2,4-Difluoro-benzenesulfinyl)-2-methanesulfonyl-6-methoxy-quinoline | HCID 22139740 | 45,9% |
Reaktionsschritte
5-(2,4-Difluoro-phenylsulfanyl)-2-methanesulfonyl-6-methoxy-quinoline 101 (230 mg) was dissolved in 9 mL (1:1:1 MeOH/THF/H2O) and was treated with 1 gram of OXONE™. After 3 hours the mixture was partitioned between CH2Cl2 and water. The product was purified by chromatography (10% MeOH/CH2Cl2) to afford 110 mg of 5-(2,4-difluoro-benzenesulfinyl)-2-methanesulfonyl-6-methoxy-quinoline 301; ([M+H]+)=398.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07049325B2 |
| Quelldatensatz | uspto-grants-2006_05 |
| ORD ID | ord-691d5b2e0f5e4ee083034e9eba731625 |
| Quellennotiz | uspto-grants-2006_05 |